منابع مشابه
RIN1 is a breast tumor suppressor gene.
Breast cancer progression is driven by altered gene expression. We show that the RIN1 gene, which encodes a RAS effector regulating epithelial cell properties, is silenced in breast tumor cell lines compared with cultured human mammary epithelial cells. We also report that RIN1 is often reduced in human breast tumor cells compared with morphologically normal breast glandular cells. At least two...
متن کاملSTOP gene Phactr4 is a tumor suppressor.
Cancer develops through genetic and epigenetic alterations that allow unrestrained proliferation and increased survival. Using a genetic RNAi screen, we previously identified hundreds of suppressors of tumorigenesis and/or proliferation (STOP) genes that restrain normal cell proliferation. Our STOP gene set was significantly enriched for known and putative tumor suppressor genes. Here, we repor...
متن کاملP53 is a tumor suppressor gene
Arnold J. Levine, 1. Cathy A. Finlay, 2 and Philip W. Hinds 3 1Institute for Advanced Study Einstein Drive Princeton, New Jersey 08540 and Cancer Institute of New Jersey 195 Little Albany St. New Brunswick, New Jersey 08903 2 Department of High Throughput Biology GlaxoSmithKline 5 Moore Drive Research Triangle Park, North Carolina 27709 3Harvard Medical School Department of Pathology Armenise 4...
متن کاملPeriod-2: a tumor suppressor gene in breast cancer
Previous reports have suggested that the ablation of the Period 2 gene (Per 2) leads to enhanced development of lymphoma and leukemia in mice. Employing immunoblot analyses, we have demonstrated that PER 2 is endogenously expressed in human breast epithelial cell lines but is not expressed or is expressed at significantly reduced level in human breast cancer cell lines. Expression of PER 2 in M...
متن کاملA candidate tumor suppressor gene in human breast cancers.
We have isolated a candidate gene (designated Brush-1) located at 13q12-q13, proximal to the retinoblastoma gene (RB1). Brush-1 codes for a 4.7-kilobase mRNA expressed at high levels in normal breast epithelium but drastically reduced in 6 of 13 breast cancer cell lines. RB1 mRNA expression is at normal levels for 5 of these 6 lines suggesting a greater importance of Brush-1 for breast cancer. ...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2007
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-07-1147